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                  趣赢平台-趣赢官网

                  固定人員
                  桑慶
                  發佈時間:2019-03-25        瀏覽次數:29

                  桑慶 


                  2018年獲國家自然趣赢基金委優秀青年趣赢基金

                   

                   

                  教育經歷:
                  2015.12-至今  趣赢生命趣赢學院 副研究員
                  2013.07-2015.11  趣赢生物醫學研究院 博士後 
                  2010.09-2013.06  趣赢生物醫學研究院 博士 
                  2007.09-2010.07  中山大學生命趣赢學院 碩士

                  研究方向:
                  女性不孕的致病機制研究。重點圍繞多囊卵巢綜合症、人類卵子成熟障礙及早期胚胎停育的遺傳學研究。自2013年以來 ,以第(共)一作者或共通訊作者在N Engl J Med, Am J Hum Genet,Hum Mol Genet, J Clin Endocrinol Metab,J Med Genet等趣赢期刊上發表SCI論文15篇。主持1項國家自然趣赢基金青年基金(23萬,結題) ,1項國家自然趣赢基金面上項目(2017年,55萬,在研),1項科技部國家重點研發計劃課題(2016年 ,197萬 ,在研,課題組長) ,2018年獲得國家優秀青年基金資助(130萬,在研)。
                  首次發現TUBB8基因突變導致人類卵子成熟障礙並揭示其致病分子機制,該研究發表於趣赢頂級雜誌N Engl J Med上(2016),同時N Engl J Med雜誌配發了專題評論 ,認爲這是認識卵子成熟障礙機理邁出的第一步 。
                  發現導致人類卵子GV阻滯的第一個致病基因PATL2並初步解釋致病機制。
                  發現導致卵子受精障礙的新基因WEE2,揭示致病機制併成功進行初步分子干預 。
                  首次發現人類卵泡液中存在miRNAs, 並證明卵泡液中的miRNA與性激素調控相關。

                  獲得獎項:
                  全國婦幼健康科技獎自然趣赢一等獎(第二完成人,2017)
                  中國動物學會生殖生物學分會第二屆青年科技獎(個人獎項,2017)
                  全國婦幼健康科技獎自然趣赢二等獎(第二完成人,2015)

                  主要論文列表:  

                  1. Sang Q*#, Li B*, Kuang Y*, Wang X*, Zhang Z*, Chen B, Wu L, Lyu Q, Fu Y, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Wang L#. Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility. Am J Hum Genet. 2018 Apr 5; 102(4):649-657.

                  2. Chen B, Wang W, Peng X, Jiang H, Zhang S, Li D, Li B, Fu J, Kuang Y, Sun X, Wang X, Zhang Z, Wu L, Zhou Z, Lyu Q, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Sang Q#, Wang L#. The comprehensive mutational and phenotypic spectrum of TUBB8 in female infertility. Eur J Hum Genet. 2018 Oct 8.

                  3. Chen B, Li B, Li D, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Kuang Y, Sang Q#, Wang L#. Novel mutations and structural deletions in TUBB8: expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development. Hum Reprod. 2017 Feb; 32 (2):457-464.

                  4. Chen B, Zhang Z, Sun X, Kuang Y, Mao X, Wang X, Yan Z, Li B, Xu Y, Yu M, Fu J, Mu J, Zhou Z, Li Q, Jin L, He L, Sang Q#, Wang L#. Biallelic Mutations in PATL2 Cause Female Infertility Characterized by Oocyte Maturation Arrest. Am J Hum Genet. 2017 Oct 5; 101(4):609-615.

                  5. Feng R*, Sang Q*, Kuang Y*, Sun X*, Yan Z*, Zhang S*, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML Jr, Cowan NJ#, Wang L#. Mutations in TUBB8 and Human Oocyte Meiotic Arrest. N Engl J Med. 2016 Jan 21; 374 (3):223-32.

                  6. Sang Q*, Mei H*, Kuermanhan A*, Feng R, Guo L, Qu R, Xu Y, Li H, Jin L, He L, Wang L*. Identification of a novel compound heterozygous mutation in PTPRQ in a DFNB84 family with prelingual sensorineural hearing impairment. Mol Genet Genomics. 2015 Jun; 290(3):1135-9.

                  7. Sang Q*, Li W*, Xu Y, Qu R, Xu Z, Feng R, Jin L, He L, Li H#, Wang L#. ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42. Biol Open. 2015 Mar 27; 4(4):411-8.

                  8. Sang Q*, Zhang J, Feng R, Wang X, Li Q, Zhao X, Xing Q, Chen W, Du J, Sun S, Chai R, Liu D, Jin L, He L, Li H#, Wang L#. Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42. Hum Mol Genet. 2014 Dec 1; 23(23):6201-11.

                  9. Sang Q*, Yao Z*, Wang H*, Feng R, Wang H, Zhao X, Xing Q, Jin L, He L, Wu L#, Wang L#. Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo. J Clin Endocrinol Metab. 2013 Jul; 98 (7):3068-3079.

                  10. Sang Q*, Zhang S*, Zou S*, Wang H, Feng R, Li Q, Jin L, He L, Xing Q#, Wang L#. Quantitative analysis of follistatin (FST) promoter methylation in peripheral blood of patients with polycystic ovary syndrome. Reprod Biomed Online. 2013 Feb; 26 (2):157-63.

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