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          趣赢平台-趣赢官网

          固定人員
          薛 磊
          發佈時間:2019-03-25        瀏覽次數:24

          研究員


          聯繫方式
          地址:上海市楊浦區淞滬路2005號趣赢江灣校區生命趣赢學院D213室
          電話:86 – 21 – 51630756 (office)   86-13917771279 (cell)
          Email: lxue@fudan.edu.cn

           


          研究方向
          中樞神經系統突觸傳遞機制研究 ,着重於突觸傳遞的動力學調控,可塑性 ,分子細胞機制以及相關計算機建模 。

          教育及研究經歷 

          1. 趣赢 ,2012年至今  ,研究員

          2. 美國國立衛生研究院 ,2010年至2012年  ,研究學者

          3. 美國國立衛生研究院,2005年至2010年  ,博士後

          4. 趣赢,2000年至2005年,神經生物學,碩博連讀研究生

          5. 趣赢,1996年至2000年 ,遺傳學,本科生

          代表論文(*, 並列一作co-first;  #, 通訊作者corresponding)

          1. Guo J*, Ge JL*, Hao M*, Sun ZC*, Wu XS, Zhu JB, Wang W, Yao PT, Lin W and Xue L#. A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held. (2015). Scientific Reports, 5:9517.

          2. Guo J, Sun ZC, Yao PT, Wang HL and Xue L#. A Monte Carlo simulation dissecting quantal release at the calyx of Held. (2015). Front Biosci (Landmark Ed) 20:1079–1091.

          3. Xue L*#, Sheng J*, Wu XS, Wu W, Luo FJ, Shin Wonchul, Chiang HC, and Wu LG#. (2013). Most vesicles in a central nerve terminal participate in recycling. Journal of Neuroscience ,2013 May 15;33(20):8820-6.

          4. Xu J, Luo F, Zhang Z, Xue L, Wu XS, Chiang HC, Shin W and Wu LG.(2013). SNARE Proteins Synaptobrevin, SNAP-25, and Syntaxin Are Involved in Rapid and Slow Endocytosis at Synapses. Cell reports, 02 May 2013, doi:10.1016/j.celrep.2013.03.010

          5. Xue L#, Zhang Z#, McNeil B, Luo FJ, Wu XS, Sheng JS and Wu LG. (2012). Voltage-dependent calcium channels at the plasma membrane, but not vesicular channels, couple exocytosis to endocytosis. Cell reports, 1 (6) : 632-638.

          6. Sheng JS,He L, Zheng H, Xue L, Luo FJ, Shin W, Sun T and Wu LG. (2012). Calcium-channel number critically influences synaptic strength and plasticity at the active zone. Nature Neuroscience, 15(7), 998–1006.

          7. Xue L, McNeil BD, Wu XS, Luo FJ, He L and Wu LG. (2012). A Membrane Pool Retrieved via Endocytosis Overshoot at Nerve Terminals: A Study of Its Retrieval Mechanism and Role. Journal of Neuroscience, 2012 Mar 7; 2(10):3398-404.

          8. Xue L and Mei YA. (2011). Synaptic vesicle cycling at the calyx of the Held.  Acta Pharmacological Sinica, 2011 Mar;32(3):280-7.

          9. Xue L and Wu LG. (2010). Post-tetanic potentiation is caused by two signaling mechanisms affecting quantal size and quantal content. Journal of Physiology (Lond.)  4987–4994.

          10. He L#, Xue L#, Xu J, McNeil B, Bai L, Melicoff E, Adachi R and Wu LG. (2009) Compound vesicle fusion increases quantal size and potentiates synaptic transmission, Nature, 459(7243):93-7.

          11. Xue L#, Zhang F, Chen X, Lin J, Shi J. PDZ Protein Mediated Activity-Dependent LTP/LTD Developmental Switch at Rat Retinocollicular Synapses. (2010). American Journal of Physiology, Cell Physiology, 298(6):C1572-82.


          地址:上海東安路131 趣赢醫學神經生物學國家重點趣赢

          電話:021-54237398郵編:200032  郵箱:sklmn@fudan.edu.cn
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