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                                                                                  趣赢平台-趣赢官网

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                                                                                  何 睿
                                                                                  發佈時間:2019-03-25        瀏覽次數:33

                                                                                  教授


                                                                                  聯繫方式
                                                                                  Email:ruihe@fudan.edu.cn

                                                                                   

                                                                                   

                                                                                   


                                                                                         趣赢基礎醫學院免疫學教授 。長期從事免疫相關炎性疾病細胞分子機制的研究,主要研究方向爲粘膜免疫和腫瘤炎症的調節機制 ,研究成果以通訊作者或第一作者在Am J Respir Crit Care Med、Allergy、Immunity、PNAS、J Allergy Clin Immunol等趣赢期刊發表 。科研方面獲得多項國家自然基金資助,並分別獲得2009年教育部“新世紀優秀人才支持計劃”資助 ,2011年上海市“浦江人才”資助, 2013年上海市“曙光學者”以及2014年國家自然基金委“優青” 。

                                                                                  學習和工作經歷

                                                                                  1. 2012.12月-至今:趣赢上海醫學院免疫學系  教授,博士生導師,課題組長

                                                                                  2. 2009.11-2012.11:趣赢上海醫學院免疫學系 副研究員  ,博士生導師,課題組長

                                                                                  3. 2004.9---2009.10:    哈佛大學波士頓兒童醫院免疫學系    博士後

                                                                                  4. 1999.9 ---2004.7:    中國協和醫科大學   醫學博士

                                                                                  5. 1994.9 ---1999.7:    華西醫科大學          臨牀醫學本科   

                                                                                  研究方向

                                                                                  免疫炎症調節

                                                                                  代表論文 (* 通訊作者)

                                                                                  1. Xiao L, Yang X, Lin Y, Li S, Jiang J, Qian S, Tang Q, He R*, Li X*. Large adipocytes function as antigen presenting cells to activate CD4+ T cells via up-regulating MHCII in obesity. Int J Obes 2015 Aug 7. [Epub ahead of print]. IF: 5.08

                                                                                  2. Lv J, Zou L, Zhao L, Yang W, Xiong Y, Li B, He R*. LTB4-BLT1 axis promotes OXA-induced contact dermatitis by directing skin homing of neutrophils and CD8+ T cells. Immunology 2015 May 9. [Epub ahead of print]. IF: 3.8

                                                                                  3. Wang L, Ray A, Jiang X, Wang JY, Basu S, Liu X, Qian T, He R, Dittel BN, Chu Y. T regulatory cells and B cells cooperate to form a regulatory loop that maintains gut homeostasis and suppresses dextran sulfate sodium-induced colitis. 2015 Mar 25. Mucosal Immunol [Epub ahead of print].

                                                                                  4. IF: 7.54

                                                                                  5. Liang M, Lv J, Zou L, Yang W, Xiong Y, Chen X, Guan M, He R*, Zou H*. A modified murine model of systemic sclerosis: bleomycin given by pump infusion induced skin and pulmonary inflammation and fibrosis.  Lab Invest. 2015 Mar;95(3):342-50. IF:3.7

                                                                                  6. Li X, Xu J, Lv Z, Wang J, Sun S, Zhu W, Wang B, He R, Qu D. Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice. Hum Vaccin Immunother. 2015 Jun 17:0. [Epub ahead of print]. IF: 2.4

                                                                                  7. Liu WR, Tian MX1, Yang LX, Lin YL, Jin L, Ding ZB, Shen YH, Peng YF, Gao DM, Zhou J, Qiu SJ, Dai Z, He R, Fan J, Shi YH. PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma. Oncotarget. 2015 Jan 20;6(2):846-61. IF:6.4

                                                                                  8. Zhao L, Yang W, Yang X, Lin Y, Lv J, Dou X, Luo Q, Dong J, Chen Z, Chu Y and He R*. Chemerin suppresses murine allergic asthma by inhibiting CCL2 production and subsequent airway recruitment of inflammatory dendritic cells. Allergy 2014 Jun;69(6):763-74. IF: 6

                                                                                  9. Lin Y, Yang X, Yue W, Xu X, Li B, Zou L and He R*. Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization. Cellular & Molecular Immunol 2014 Jul;11(4):355-66. IF: 4.1

                                                                                  10. Yin Q, Xu X, Lin Y, Lv J, Zhao L, and He R*. Ultraviolet B irradiation induces skin accumulation of plasmacytoid dendritic cells: A possible role for chemerin. Autoimmunity   2014 May;47(3):185-92. IF: 2.7

                                                                                  11. Wang L, Zhao L, Lv J, Yin Q, Liang X, Chu Y and He R*. BLT1-dependent alveolar recruitment of CD4+CD25+ Foxp3+ regulatory T cells is important for resolution of acute lung injury. Am J Respir Crit Care Med 2012, 186(10):989-98.  IF: 13

                                                                                  12. Oyoshi MK, He R (Co-first author), Li Y, Mondal, S, Yoon J, Afshar R, Chen M ,Lee DM, Luo HR, Luster AD, Cho JS, Miller LS, Larson A, Murphy GF and Geha RS. LTB4 driven neutrophil recruitment to the skin is essential for allergic skin inflammation Immunity 2012, 37(4):747-58. IF: 21.6

                                                                                  13. Oyoshi MK, He R, Elkhal A, Kawamoto S, Lewis C, Kanaoka Y, Austen KF, and Geha RS. Eosinophil-derived LTC4 signals via CysLT2R to promote skin thickening and collagen deposition in a mouse model of allergic skin inflammation. Proc Natl Acad Sci U S A 2012;109(13):4992-7. IF: 9.7

                                                                                  14. He R, Oyoshi MK, Wang JY, Hodge MR, Jin H, and Geha RS. The prostaglandin D(2) receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. J Allergy Clin Immunol.  2010; 126(4):784-90. IF: 11.5

                                                                                  15. He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S , Bryce P, Freyschmidt EJ, McKenzie AJ, Umetsu DT, Oettgen HC and Geha RS. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. J Allergy Clin Immunol 2009; 124(4):761-770.e1. IF: 11.5

                                                                                  16. He R and Geha RS. Thymic Stromal Lymphopoietin. Ann N Y Acad Sci. 2010;1183:13-24. IF: 4.4

                                                                                  17. Oyoshi MK, Elkhal A, Kumar L, Scott J, Koduru S, He R, Leung DY, Howell MD, Oettgen HC, Murphy GF, and Geha RS. IL-17 promotes dissemination of vaccinia virus in a mouse model of eczema vaccinatum. Proc Natl Acad Sci U S A 2009;106(35):14954-9. IF: 9.7

                                                                                  18. Oyoshi MK, He R, Kumar L, Yoon J and Geha RS. Cellular and molecular mechanisms in Atopic dermatitis. Adv Immunol 2009;102:135-226. IF: 6

                                                                                  19. He R, Oyoshi MK, Garibyan L, Kumar L, Ziegler SF and Geha RS. TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc Natl Acad Sci U S A 2008; 105(33):11875-80.

                                                                                  20. IF: 9.7

                                                                                  21. He R, Oyoshi MK, Jin H, Geha RS. Epicutaneous antigen exposure induces a TH17 response that drives airway inflammation after inhalation challenge. Proc Natl Acad Sci USA 2007; 104(40): 15817-22. IF: 9.7

                                                                                  22. Jin H, He R ( Co-first author), Oyoshi MK, Geha RS. Animal models of atopic dermatitis. J Invest Dermatol; 2009; 129(1):31-40.  IF: 7.2

                                                                                  23. Yalcindag A, He R*( Co-first author), Laouini D, Alenius H, Carroll M, Oettgen HC, Geha RS. The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen. J Allergy Clin Immunol. 2006; 117(6):1455-61. IF: 11.5

                                                                                  24. Elkhal A, Pichavant M, He R, Scott J, Meyer E, Goya S, Geha RS, Umetsu DT. CD1d restricted natural killer T cells are not required for allergic skin inflammation. J Allergy Clin Immunol. 2006;118(6):1363-8. IF: 11.5

                                                                                  25. Xu ZS, Liu YJ, Lv LL, Han ZB, He R, Lu SH, Wang T, Xu B, Chen ZZ, Han ZC. Bone marrow stromal cells transduced with human hemangiopoietin gene support hematopoiesis in vitro. Haematologica. 2005;90(2):157-65. IF: 5.87

                                                                                  26. He R, Liu B, Yang C, Yang RC, Tobelem G, Han ZC. Inhibition of K562 leukemia angiogenesis and growth by expression of antisense vascular endothelial growth factor (VEGF) sequence. Cancer Gene Ther. 2003;10(12):879-86. IF: 2.55

                                                                                  著作
                                                                                  《間充質幹細胞基礎與臨牀》 趣赢出版社 2012年4月第一版,
                                                                                  撰寫第三章 “間充質幹細胞免疫調節的機制”
                                                                                   

                                                                                  參編教材
                                                                                  2014年“全國高等教育醫學數字化規劃教材”《醫學免疫學》編委

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