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                                                                  趣赢平台-趣赢官网

                                                                  固定人員
                                                                  陳道峯
                                                                  發佈時間:2019-03-25        瀏覽次數:33

                                                                  教授

                                                                   

                                                                  聯繫方式
                                                                  Email:dfchen@shmu.edu.cn

                                                                   

                                                                   


                                                                          趣赢藥學院生藥學教研室主任、教授(二級)、博士生導師。兼任國家藥典委員會委員、世界中醫藥學會聯合會中藥化學/中藥鑑定專業委員會副會長等多項學術職務。1986年畢業於上海醫科大學藥學專業  ,獲學士學位,1991年獲中國藥科大學生藥學博士學位,同年任教於上海醫科大學,1993年晉升爲副教授 ,1997年晉升爲教授 ,1999年遴選爲博士生導師。1990、1998年赴日本富山醫科藥科大學和美國阿拉巴馬大學伯明翰分校學術進修,2002和2006年以訪問教授身份赴美國北卡羅萊納大學藥學院和日本九州大學藥學院合作研究與講學。主要研究領域爲常用中藥的藥效物質基礎及其作用機制  ,在五味子科藥用植物和清熱解毒中藥的藥效物質基礎研究方面具有特色 。主持和完成科技部“重大新藥創制”重大專項、國家傑出青年趣赢基金、國家自然趣赢基金重點項目等省部級以上科研項目30餘項, 發表研究論文210餘篇, 其中SCI論文120餘篇, 副主編《中華人民共和國藥典英文版》、《植物成分分析》和《生藥學》等著作10餘部,獲得授權發明專利50餘項 。曾獲得國家中醫藥科技進步一等獎、教育部自然趣赢一等獎、教育部首屆青年教師獎以及國務院政府特殊津貼等獎勵 。教育部跨世紀人才、上海市曙光學者、上海市優秀學科帶頭人、國家傑出青年趣赢基金獲得者 。Elsevier中國高被引學者 。

                                                                   

                                                                  研究方向

                                                                  中藥藥效物質基礎與質量控制

                                                                   

                                                                  代表論文

                                                                  1. HY Zhu, XX Lu, LJ Ling, H Li, YY Ou, XL Shi, Y Lu, YY Zhang, DF Chen*. Houttuynia cordata Polysaccharides Ameliorate Pneumonia Severity and Intestinal Injury in Mice with Influenza Virus Infection. Journal of Ethnopharmacology 2018, 218: 90-99

                                                                  2. Q Wen, Z Cao, Y Lu, DF Chen*. Anticomplement Triterpenoids from the Roots of Ilex asprella. Bioorg Med Chem Lett 2017, 27: 880-886

                                                                  3. YY Ou, Y Jiang, H Li, YY Zhang, Y Lu, DF Chen*. Polysaccharides from Arnebia euchroma Ameliorated Endotoxic Fever and Acute Lung Injury in Rats through Inhibiting Complement System. Inflammation 2017, 40(1): 275-284

                                                                  4. P Jiang, Y Lu, DF Chen*. Authentication of Schisandra chinensis and Schisandra sphenanthera in Chinese Patent Medicines. J Pharm Biomed Anal 2016, 131: 263-271 ( SCI)

                                                                  5. DS Du, ZH Cheng, DF Chen*. Structure Characterization of Two Novel Polysaccharides Isolated from the Spikes of Prunella vulgaris and Their Anticomplement Activities. Journal of Ethnopharmacology 2016, 193: 345-353

                                                                  6. M Yan, Y Lu,CH Chen,Y Zhao, KH Lee, DF Chen*. Stelleralides D–J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme. J Nat Prod 2015, 78(11): 2712-2718

                                                                  7. LY Pan, HB Weng, H Li, ZZ Liu, YY Xu, CJ Zhou, XX Lu, Xy Su, YY Zhang, DF Chen*. Therapeutic Effects of Bupleurum Polysaccharides in Streptozotocin Induced Diabetic Mice. PLOS ONE 2015, 10(7): e0133212

                                                                  8. YY Xu, YY Zhang, YY Ou, XX Lu, LY Pan, H Li, Y Lu, DF Chen*. Houttuynia cordata Thunb. Polysaccharides Ameliorates Lipopolysaccharide-induced Acute Lung Injury in Mice. Journal of Ethnopharmacology 2015, 173: 81-90

                                                                  9. WH Song, ZH Cheng, DF Chen*. Anticomplement Monoterpenoid Glucosides from the Root Bark of Paeonia suffruticosa. J Nat Prod 2014, 77(1): 42-48

                                                                  10. J Wu, YY Zhang, L Guo, H Li, DF Chen*. Bupleurum Polysaccharides Attenuates Lipopolysaccharide-induced Inflammation via Modulating Toll-Like Receptor 4 Signaling. PLOS ONE 2013, 8(10): e78051

                                                                  11. JY Xie, H Li, HY Di, XQ Cheng, YY Zhang, DF Chen*. Bupleurum chinense DC Polysaccharides Attenuates Lipopolysaccharide-induced Acute Lung Injury in Mice. Phytomedicine 2012, 19(2): 130-137

                                                                  12. XQ Cheng, H Li, XL Yue, JY Xie, YYZhang, HY Di, DF Chen*. Macrophage Immunomodulatory Activity of the Polysaccharides from the Roots of Bupleurum smithii var. parvifolium. Journal of Ethnopharmacology 2010, 130(2): 363-368

                                                                  13. Q Wang, TH Chen, KF Bastow, KH Lee, DF Chen*. Altaicalarins A-D, Cytotoxic Bisabolane Sesquiterpenes from Ligularia altaica. J Nat Prod 2010, 73(2): 139-142

                                                                  14. WH Ma, Y Lu, H Huang, P Zhou, DF Chen*. Schisanwilsonins A-G and Related Anti-HBV Lignans from the Fruits of Schisandra wilsoniana. Bioorg Med Chem Lett 2009, 19(17): 4958-4962

                                                                  15. WH Ma, H Huang, P Zhou, DF Chen*. Schisanwilsonenes A-C, Anti-HBV Carotane Sesquiterpenoids from the Fruits of Schisandra wilsoniana. J Nat Prod 2009, 72(4): 676-678

                                                                  16. Y Lu, DF Chen*. Analysis of Schisandra chinensis and Schisandra sphenanthera. Journal of Chromatography A 2009, 1216(11): 1980-1990

                                                                  17. T Zhang, DF Chen*. Anticomplementary Principles of a Chinese Multiherb Remedy for the Treatment and Prevention of SARS. Journal of Ethnopharmacology 2008, 117(2): 351-361

                                                                  18. H Xu, YY Zhang, JW Zhang, DF Chen*.Isolation and Characterization of an Anti-complementary Polysaccharide D3-S1 from the Roots of Bupleurum smithii. International Immunopharmacology 2007, 7(2):175-182

                                                                  19. M Chen, N. Kilgore, KH Lee, DF Chen*. Rubrisandrins A and B, Lignans and Related Anti-HIV Compounds from Schisandra rubriflora. J Nat Prod 2006, 69(12):1697-1701

                                                                  20. PL Ding, ZX Liao, H Huang, P Zhou, DF Chen*. (+)-12a-Hydroxysophocarpine, a New Quinolizidine Alkaloid and Related Anti-HBV Alkaloids from Sophora flavescens. Bioorg Med Chem Lett 2006, 16(5): 1231-1235

                                                                  21. YQ Yu, PL Ding, DF Chen*. Determination of Quinolizidine Alkaloids in Sophora Medicinal Plants by Capillary Electrophoresis. Analytica Chimica Acta 2004, 523(1): 15-20

                                                                  22. DF Chen*, SX Zhang, M Kozuka, QZ Sun, J Feng, Q Wang, T Mukainaka, Y Nobukuni, H Tokuda, H Nishino, HK Wang, SL Morris-Natschke, KH Lee. Interiotherins C and D, Two New Lignans from Kadsura interior and Antitumor-promoting Effects of Related Neolignans on Epstein-Barr Virus Activation. J Nat Prod 2002, 65(9):1242-1245

                                                                  23. DF Chen*, SX Zhang, HK Wang, SY Zhang, QZ Sun, LM Cosentino and KH Lee. Novel Anti-HIV Lancilactone C and Related Triterpenes  from Kadsura lancilimba. J Nat Prod 1999, 62(1): 94 -97

                                                                  24. DF Chen*, SX Zhang, L Xie, JX Xie, K Chen, Y Kashiwada, BN Zhou, P Wang, LM Cosentino and KH Lee.  Anti-AIDS Agents 26. Structure-Activity Correlations of Gomisin G-Related Anti-HIV Lignans from Kadsura interior and of Related Synthetic Analogues. Bioorg Med Chem 1997, 5(8):1715-1723

                                                                  25. DF Chen*, SX Zhang, K Chen, BN Zhou, P Wang, LM Cosentino and KH Lee.  Two New Lignans, Interiotherins A and B, as Anti-HIV Principles from Kadsura interior. J Nat Prod 1996, 59(11): 1066-1068

                                                                  聯繫方式:電話:021-51980135;電子信箱:dfchen@shmu.edu.cn

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