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                                                          趣赢平台-趣赢官网

                                                          固定人員
                                                          魏園園
                                                          發佈時間:2019-03-25        瀏覽次數:33

                                                          研究員


                                                          聯繫方式
                                                          Tel: +86-21-54237730
                                                          Email:  ywei@fudan.edu.cn
                                                          地址:上海市徐彙區東安路130號13號樓,200237 上海

                                                           


                                                          研究方向
                                                                 動脈粥樣硬化引起的心腦血管疾病已成爲世界上致死率最高的疾病之一,但由於發病機制的複雜性,對於這種慢性炎症疾病的預防與治療在趣赢上仍舊是一個難題 。巨噬細胞在血管內膜下的積累是造成動脈粥樣硬化發展的主要原因 ,基於動脈粥樣硬化斑塊內巨噬細胞的表型呈現異質性和可塑性的特點,本人的研究聚焦動脈粥樣硬化過程中巨噬細胞的代謝變化、極性活化以及血管內膜通透性及其調節機制,特別是microRNA在這些過程中的作用與功能,旨在發現新型心血管藥物的靶點 。

                                                          代表論文

                                                          1. Wei Y*, Gurung R, Corbalán-Campos J, Natarelli L, Exner N, Erhard F, Greulich F, Zhu M, Geißler C, Uhlenhaut NH, Zimmer R, Schober A*. Dicer in Macrophages Prevents Atherosclerosis by Promoting Mitochondrial Oxidative Metabolism. Circulation. 2018; 138(18):2007-2020. *co-corresponding author. (Impact factor: 18.9)

                                                          2. Wei Y#, Nazari-Jahantigh M#, Chan L, Zhu M, Heyll K, Corbalán-Campos J, Hartmann P, Thiemann A, Weber C, Schober A. The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis. Circulation. 2013;127(15):1609-1619. #co-first author. (Impact factor: 18.9)

                                                          3. Wei Y, Zhu M, Corbalán-Campos J, Heyll K, Weber C, Schober A. Regulation of Csf1r and Bcl6 in macrophages mediates the stage-specific effects of microRNA-155 on atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35(4):796-803. (Impact factor: 6.1)

                                                          4. Wei Y, Chen S, Yang P, Ma Z, Kang L. Characterization and comparative profiling of the small rna transcriptomes in two phases of locust. Genome biology. 2009;10:R6. (Impact factor: 13.2)

                                                          5. He J #, Chen Q#, Wei Y#, Jing F, Yang M, Hao S, Guo X, Chen D, Kang L. MicroRNA-276 promotes egg hatching synchrony by upregulating brm in locusts. Proc Natl Acad Sci U S A. 2016;113(3):584-9. (Impact factor: 9.5). #co-first author.

                                                          6. Yang M#, Wei Y#, Jiang F#, Wang Y, Guo X, He J, Kang L. MicroRNA-133 inhibits behavioral aggregation by controlling dopamine synthesis in locusts. PLoS Genet, 2014;10(2):e1004206. #co-first author. (Impact factor: 5.5) (Recommended in F1000Prime (http://f1000.com/prime/718293925))

                                                          7. Wei Y, Schober A. MicroRNA regulation of macrophages in human pathologies. Cell Mol Life Sci. 2016; 73(18): 3473-95. (Impact factor: 6.7)

                                                          8. Wei Y, Zhu M, Schober A. Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer. Int J Mol Sci. 2018;19(6). (Impact factor: 3.7)

                                                          9. Wei Y, Schober A, Weber C. Pathogenic arterial remodeling: The good and bad in micrornas. Am J Physiol Heart Circ Physiol. 2013;304:H1050-9. (Impact factor: 3.6)

                                                          10. Wei Y, Nazari-Jahantigh M, Neth P, Weber C, Schober A. Microrna-126, -145, and -155:  A therapeutic triad in atherosclerosis? Arterioscler Thromb Vasc Biol. 2013;33:449-454.  (Impact factor: 6.1)

                                                          11. Natarelli L, Geißler C, Csaba G, Wei Y, Zhu M, di Francesco A, Hartmann P, Zimmer R, Schober A. Nat Commun. 2018;9(1):2645. (Impact factor: 12.4)

                                                          12. Zhu M, Wei Y, Geißler C, Abschlag K, Corbalán Campos J, Hristov M, Möllmann J, Lehrke M, Karshovska E, Schober A. Hyperlipidemia-Induced MicroRNA-155-5p Improves β-Cell Function by Targeting Mafb. Diabetes. 2017 66(12):3072-3084. (Impact factor: 7.3)

                                                          13. Zahedi F, Nazari-Jahantigh M, Zhou Z, Subramanian P, Wei Y, Grommes J, Offermanns S, Steffens S, Weber C, Schober A. Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. Cell Mol Life Sci. 2017;74(2):359-372. (Impact factor: 6.7)

                                                          14. Hartmann P, Zhou Z, Natarelli L, Wei Y, Nazari-Jahantigh M, Zhu M, Grommes J, Steffens S, Weber C, Schober A. Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nat Commun. 2016;7:10521. (Impact factor: 12.4)

                                                          15. Schober A#, Nazari-Jahantigh M#, Wei Y, Bidzhekov K, Gremse F, Grommes J, Megens RT, Heyll K, Noels H, Hristov M, Wang S, Kiessling F, Olson EN, Weber C. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1.  Nat Med. 2014;20(4):368-76. (Impact factor: 32.6) (Recommended in F1000Prime (http://f1000.com/prime/718293958))

                                                          16. Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 2014;124(5):2136-46. (Impact factor: 13.3)

                                                          17. Nazari-Jahantigh M, Wei Y, Noels H, Akhtar S, Zhou Z, Koenen RR, Heyll K, Gremse F, Kiessling F, Grommes J, Weber C, Schober A. Microrna-155 promotes atherosclerosis by repressing bcl6 in macrophages. J Clin Invest. 2012;122:4190-4202. (Impact factor: 13.3)

                                                          18. Nazari-Jahantigh M, Wei Y, Schober A. The role of micrornas in arterial remodelling.  Thromb Haemost 2012;107:611-618. (Impact factor: 5)

                                                          19. Wang Y, Jiang F, Wang H, Song T, Wei Y, Yang M, Zhang J, Kang L. Evidence for the expression of abundant microRNAs in the locust genome. Sci Rep. 2015;5:13608. (Impact factor: 4.1)

                                                          20. Chen S, Yang P, Jiang F, Wei Y, Ma Z, Kang L. De novo analysis of transcriptome dynamics in the migratory locust during the development of phase traits. PLoS One. 2010;5(12):e15633. (Impact factor: 2.8)

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